A genome‐wide linkage analysis of dementia in the Amish
Identifieur interne : 002178 ( Main/Corpus ); précédent : 002177; suivant : 002179A genome‐wide linkage analysis of dementia in the Amish
Auteurs : Daniel W. Hahs ; Jacob L. Mccauley ; Amy E. Crunk ; Lynne L. Mcfarland ; Perry C. Gaskell ; Lan Jiang ; Susan H. Slifer ; Jeffery M. Vance ; William K. Scott ; Kathleen A. Welsh-Bohmer ; Stephanie R. Johnson ; Charles E. Jackson ; Margaret A. Pericak-Vance ; Jonathan L. HainesSource :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2006-03-05.
English descriptors
Abstract
Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community. © 2006 Wiley‐Liss, Inc.
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DOI: 10.1002/ajmg.b.30257
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Hahs</name><affiliation><mods:affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Mccauley, Jacob L" sort="Mccauley, Jacob L" uniqKey="Mccauley J" first="Jacob L." last="Mccauley">Jacob L. Mccauley</name><affiliation><mods:affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Crunk, Amy E" sort="Crunk, Amy E" uniqKey="Crunk A" first="Amy E." last="Crunk">Amy E. Crunk</name><affiliation><mods:affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Mcfarland, Lynne L" sort="Mcfarland, Lynne L" uniqKey="Mcfarland L" first="Lynne L." last="Mcfarland">Lynne L. Mcfarland</name><affiliation><mods:affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author><author><name sortKey="Gaskell, Perry C" sort="Gaskell, Perry C" uniqKey="Gaskell P" first="Perry C." last="Gaskell">Perry C. 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Pericak-Vance</name><affiliation><mods:affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</mods:affiliation></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation><mods:affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-03-05">2006-03-05</date><biblScope unit="volume">141B</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="160">160</biblScope><biblScope unit="page" to="166">166</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">95E022CF70E83D3D50373AEDA540EA33F7DEAC5B</idno><idno type="DOI">10.1002/ajmg.b.30257</idno><idno type="ArticleID">AJMG30257</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer's Disease</term><term>chromosome 10</term><term>chromosome 4</term><term>microsatellites</term><term>screen</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community. © 2006 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Daniel W. Hahs</name><affiliations><json:string>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Jacob L. McCauley</name><affiliations><json:string>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Amy E. Crunk</name><affiliations><json:string>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Lynne L. McFarland</name><affiliations><json:string>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Perry C. Gaskell</name><affiliations><json:string>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>Lan Jiang</name><affiliations><json:string>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item><json:item><name>Susan H. Slifer</name><affiliations><json:string>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>Jeffery M. Vance</name><affiliations><json:string>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>William K. Scott</name><affiliations><json:string>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>Kathleen A. Welsh‐Bohmer</name><affiliations><json:string>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>Stephanie R. Johnson</name><affiliations><json:string>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>Charles E. Jackson</name><affiliations><json:string>Scott & White, Temple, Texas</json:string></affiliations></json:item><json:item><name>Margaret A. Pericak‐Vance</name><affiliations><json:string>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</json:string></affiliations></json:item><json:item><name>Jonathan L. Haines PhD</name><affiliations><json:string>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's Disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microsatellites</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>screen</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chromosome 4</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>chromosome 10</value></json:item></subject><articleId><json:string>AJMG30257</json:string></articleId><language><json:string>eng</json:string></language><abstract>Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community. © 2006 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>7.028</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1164</abstractCharCount><pdfWordCount>5888</pdfWordCount><pdfCharCount>39095</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>169</abstractWordCount></qualityIndicators><title>A genome‐wide linkage analysis of dementia in the Amish</title><genre><json:string>article</json:string></genre><host><volume>141B</volume><publisherId><json:string>AJMG</json:string></publisherId><pages><total>7</total><last>166</last><first>160</first></pages><issn><json:string>1552-4841</json:string></issn><issue>2</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1552-485X</json:string></eissn><title>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><doi><json:string>10.1002/(ISSN)1552-485X</json:string></doi></host><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1002/ajmg.b.30257</json:string></doi><id>95E022CF70E83D3D50373AEDA540EA33F7DEAC5B</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/95E022CF70E83D3D50373AEDA540EA33F7DEAC5B/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/95E022CF70E83D3D50373AEDA540EA33F7DEAC5B/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/95E022CF70E83D3D50373AEDA540EA33F7DEAC5B/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A genome‐wide linkage analysis of dementia in the Amish</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2006</date></publicationStmt><notesStmt><note type="content">*Daniel W. Hahs and Jacob L. McCauley contributed equally to this article.</note><note>NIH/NIA - No. AG19085; No. AG19757; No. AG19726;</note><note>Vanderbilt University</note><note>Vanderbilt General Clinical Research Center - No. M01 RR‐00095;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A genome‐wide linkage analysis of dementia in the Amish</title><author><persName><forename type="first">Daniel W.</forename><surname>Hahs</surname></persName><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation></author><author><persName><forename type="first">Jacob L.</forename><surname>McCauley</surname></persName><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation></author><author><persName><forename type="first">Amy E.</forename><surname>Crunk</surname></persName><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation></author><author><persName><forename type="first">Lynne L.</forename><surname>McFarland</surname></persName><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation></author><author><persName><forename type="first">Perry C.</forename><surname>Gaskell</surname></persName><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">Lan</forename><surname>Jiang</surname></persName><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation></author><author><persName><forename type="first">Susan H.</forename><surname>Slifer</surname></persName><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">Jeffery M.</forename><surname>Vance</surname></persName><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">William K.</forename><surname>Scott</surname></persName><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">Kathleen A.</forename><surname>Welsh‐Bohmer</surname></persName><affiliation>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">Stephanie R.</forename><surname>Johnson</surname></persName><affiliation>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">Charles E.</forename><surname>Jackson</surname></persName><affiliation>Scott & White, Temple, Texas</affiliation></author><author><persName><forename type="first">Margaret A.</forename><surname>Pericak‐Vance</surname></persName><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation></author><author><persName><forename type="first">Jonathan L.</forename><surname>Haines</surname></persName><roleName type="degree">PhD</roleName><note type="correspondence"><p>Correspondence: Center for Human Genetics Research, 519 Light Hall, Vanderbilt University Medical Center, Nashville, TN 37232.</p></note><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation></author></analytic><monogr><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="pISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><idno type="DOI">10.1002/(ISSN)1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-03-05"></date><biblScope unit="volume">141B</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="160">160</biblScope><biblScope unit="page" to="166">166</biblScope></imprint></monogr><idno type="istex">95E022CF70E83D3D50373AEDA540EA33F7DEAC5B</idno><idno type="DOI">10.1002/ajmg.b.30257</idno><idno type="ArticleID">AJMG30257</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. 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affiliationRef="#af2"><personName><givenNames>Jeffery M.</givenNames><familyName>Vance</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af2"><personName><givenNames>William K.</givenNames><familyName>Scott</familyName></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Kathleen A.</givenNames><familyName>Welsh‐Bohmer</familyName></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Stephanie R.</givenNames><familyName>Johnson</familyName></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Charles E.</givenNames><familyName>Jackson</familyName></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Margaret A.</givenNames><familyName>Pericak‐Vance</familyName></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Jonathan L.</givenNames><familyName>Haines</familyName><degrees>PhD</degrees></personName><contactDetails><email>Jonathan@chgr.mc.vanderbilt.edu</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Scott & White, Temple, Texas</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Alzheimer's Disease</keyword><keyword xml:id="kwd2">microsatellites</keyword><keyword xml:id="kwd3">screen</keyword><keyword xml:id="kwd4">chromosome 4</keyword><keyword xml:id="kwd5">chromosome 10</keyword></keywordGroup><fundingInfo><fundingAgency>NIH/NIA</fundingAgency><fundingNumber>AG19085</fundingNumber><fundingNumber>AG19757</fundingNumber><fundingNumber>AG19726</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Vanderbilt University</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Vanderbilt General Clinical Research Center</fundingAgency><fundingNumber>M01 RR‐00095</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community. © 2006 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Daniel W. Hahs and Jacob L. McCauley contributed equally to this article.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A genome‐wide linkage analysis of dementia in the Amish</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Linkage to Dementia in the Amish</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A genome‐wide linkage analysis of dementia in the Amish</title></titleInfo><name type="personal"><namePart type="given">Daniel W.</namePart><namePart type="family">Hahs</namePart><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jacob L.</namePart><namePart type="family">McCauley</namePart><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amy E.</namePart><namePart type="family">Crunk</namePart><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lynne L.</namePart><namePart type="family">McFarland</namePart><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Perry C.</namePart><namePart type="family">Gaskell</namePart><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lan</namePart><namePart type="family">Jiang</namePart><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susan H.</namePart><namePart type="family">Slifer</namePart><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffery M.</namePart><namePart type="family">Vance</namePart><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William K.</namePart><namePart type="family">Scott</namePart><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathleen A.</namePart><namePart type="family">Welsh‐Bohmer</namePart><affiliation>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephanie R.</namePart><namePart type="family">Johnson</namePart><affiliation>Joseph & Kathleen Bryan ADRC/Division of Neurology, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles E.</namePart><namePart type="family">Jackson</namePart><affiliation>Scott & White, Temple, Texas</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Margaret A.</namePart><namePart type="family">Pericak‐Vance</namePart><affiliation>Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan L.</namePart><namePart type="family">Haines</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee</affiliation><description>Correspondence: Center for Human Genetics Research, 519 Light Hall, Vanderbilt University Medical Center, Nashville, TN 37232.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-03-05</dateIssued><dateCaptured encoding="w3cdtf">2005-06-02</dateCaptured><dateValid encoding="w3cdtf">2005-09-26</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">86</extent><extent unit="words">7186</extent></physicalDescription><abstract lang="en">Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome‐wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407‐microsatellite‐marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two‐point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two‐point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community. © 2006 Wiley‐Liss, Inc.</abstract><note type="content">*Daniel W. Hahs and Jacob L. McCauley contributed equally to this article.</note><note type="funding">NIH/NIA - No. AG19085; No. AG19757; No. AG19726; </note><note type="funding">Vanderbilt University</note><note type="funding">Vanderbilt General Clinical Research Center - No. M01 RR‐00095; </note><subject lang="en"><genre>Keywords</genre><topic>Alzheimer's Disease</topic><topic>microsatellites</topic><topic>screen</topic><topic>chromosome 4</topic><topic>chromosome 10</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title></titleInfo><titleInfo type="abbreviated"><title>Am. J. Med. Genet.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1552-4841</identifier><identifier type="eISSN">1552-485X</identifier><identifier type="DOI">10.1002/(ISSN)1552-485X</identifier><identifier type="PublisherID">AJMG</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>141B</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>160</start><end>166</end><total>7</total></extent></part></relatedItem><relatedItem type="preceding"><titleInfo><title>American Journal of Medical Genetics</title></titleInfo><identifier type="ISSN">0148-7299</identifier><identifier type="ISSN">1096-8628</identifier><part><date point="end">2004</date></part></relatedItem><identifier type="istex">95E022CF70E83D3D50373AEDA540EA33F7DEAC5B</identifier><identifier type="DOI">10.1002/ajmg.b.30257</identifier><identifier type="ArticleID">AJMG30257</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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